Semaglutide

Semaglutide (CAS 910463-68-2) is a synthetic, acylated glucagon-like peptide-1 (GLP-1) receptor agonist engineered for an extended half-life through albumin binding.

Mechanism of action. In research models, semaglutide selectively activates the GLP-1 receptor, a key node of the incretin system. Studies focus on its effects on glucose-dependent insulin secretion, glucagon suppression, gastric-emptying models, and central satiety signaling.

Research applications. A standard single-agonist reference in metabolic and receptor-pharmacology research. Published clinical programs (SUSTAIN and STEP) characterized its effects on glycemic and body-weight endpoints in study subjects.

Supplied as a lyophilized powder, ≥99% HPLC purity; Certificate of Analysis available on request. Available for laboratory and research purposes only.